CPI-4203

• Description :

  CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG) . CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].

• UNSPSC :

  12352005

• Target :

  Histone Demethylase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cpi-4203.html

• Purity :

  99.0

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming)

• Smiles :

  N#CC1=C(N2N=C1)NC(C3=C(C=CC=C3)C)=C(C2=O)CC

• Molecular Formula :

  C16H14N4O

• Molecular Weight :

  278.31

• References & Citations :

  [1]Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12 (7) :531-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1628214-07-2]