CPI-4203

• Description:

  CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG) . CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].

• UNSPSC:

  12352005

• Target:

  Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cpi-4203.html

• Purity:

  99.0

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming)

• Smiles:

  N#CC1=C(N2N=C1)NC(C3=C(C=CC=C3)C)=C(C2=O)CC

• Molecular Formula:

  C16H14N4O

• Molecular Weight:

  278.31

• References & Citations:

  [1]Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12 (7) :531-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1628214-07-2]