EDP-420

• Description :

  EDP-420 (EP-013420; S-013420) is an orally active antibacterial agent. EDP-420 inhibits the Mycobacterium avium complex (MAC) in macrophages. EDP-420 reduces bacterial counts in a mouse model of macrolide infection. EDP-420 inhibits pneumococcal activity in a rabbit model of meningitis. EDP-420 can be used in research on inflammatory infectious diseases such as meningitis[1][2].

• CAS Number :

  [736992-12-4]

• Product Name Alternative :

  EP-013420; S-013420

• UNSPSC :

  12352005

• Target :

  Bacterial

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection; Inflammation/Immunology

• Smiles :

  C[C@]12[C@@H]([C@H](C([C@H](C(O[C@@H]([C@@](O)([C@@](OC/C(CO2)=N\OCC3=CN=C(N4C=CC=N4)C=C3)([H])[C@H](/C([C@@H](C1)C)=N/C(C)=O)C)C)CC)=O)C)=O)C)O[C@H]5[C@@H]([C@H](C[C@H](O5)C)N(C)C)O

• Molecular Formula :

  C43H64N6O11

• Molecular Weight :

  841.00

• References & Citations :

  [1]Bermudez LE, et al. EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. Antimicrob Agents Chemother. 2007 May;51 (5) :1666-70. |[2]Stucki A, et al. Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model. J Antimicrob Chemother. 2008 Mar;61 (3) :665-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2