EDP-420

CAT: 0804-HY-106422Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106422Size:1 Each
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Description
EDP-420 (EP-013420; S-013420) is an orally active antibacterial agent. EDP-420 inhibits the Mycobacterium avium complex (MAC) in macrophages. EDP-420 reduces bacterial counts in a mouse model of macrolide infection. EDP-420 inhibits pneumococcal activity in a rabbit model of meningitis. EDP-420 can be used in research on inflammatory infectious diseases such as meningitis[1][2].
CAS Number
[736992-12-4]
Product Name Alternative
EP-013420; S-013420
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection; Inflammation/Immunology
Smiles
C[C@]12[C@@H]([C@H](C([C@H](C(O[C@@H]([C@@](O)([C@@](OC/C(CO2)=N\OCC3=CN=C(N4C=CC=N4)C=C3)([H])[C@H](/C([C@@H](C1)C)=N/C(C)=O)C)C)CC)=O)C)=O)C)O[C@H]5[C@@H]([C@H](C[C@H](O5)C)N(C)C)O
Molecular Formula
C43H64N6O11
Molecular Weight
841.00
References & Citations
[1]Bermudez LE, et al. EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. Antimicrob Agents Chemother. 2007 May;51 (5) :1666-70. |[2]Stucki A, et al. Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model. J Antimicrob Chemother. 2008 Mar;61 (3) :665-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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