TAN-420E

• Description:

  TAN-420E (Dihydroherbimycin A) is an antibiotic, that can be isolated from the fermentation product of Streptomyces hygroscopicus. TAN-420E exhibits cytotoxicity in cancer cells P-388 and KB. TAN-420E scavenges DPPH free radicals with an IC50 of 1.3 μM[1][2].

• Product Name Alternative:

  Dihydroherbimycin A

• UNSPSC:

  12352005

• Target:

  Antibiotic; Reactive Oxygen Species (ROS)

• Related Pathways:

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Cancer; Infection

• Smiles:

  C[C@H]1C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(C)\C(NC2=C(O)C([C@@H]1OC)=CC(O)=C2)=O

• Molecular Formula:

  C30H44N2O9

• Molecular Weight:

  576.68

• References & Citations:

  [1]Lin LZ, et al., 1H-nmr analysis of herbimycins and dihydro-herbimycins. J Nat Prod. 1988 Nov-Dec;51 (6) :1161-5|[2]Chang HB, et al., Antioxidant properties of dihydroherbimycin A from a newly isolated Streptomyces sp. Biotechnol Lett. 2007 Apr;29 (4) :599-603.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [91700-93-5]