LMP7/LMP2-IN-1

LMP7/LMP2-IN-1

• UNSPSC Description: LMP7/LMP2-IN-1 (Compound 19) is the orally active inhibitor for immunoproteasome subunits LMP7 and LMP2 with IC50 of 257 and 10 nM. LMP7/LMP2-IN-1 reduces the generation of antibody, downregulates the cells in spleen germinal center B and in plasma in NP-OVA-immunized mice, and can be used in research about autoimmune diseases[1].
• Target Antigen: Proteasome
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/lmp7-lmp2-in-1.html
• Smiles: OB(O)[C@@H](NC(C1=CN(C2CCCCC2)N=N1)=O)C3CCCCC3
• Molecular Weight: 334.22
• References & Citations: [1]Arai Y, et al., Optimization of α-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 (β5i)/LMP2 (β1i) dual inhibitor. Bioorg Med Chem. 2024 Jul 15;109:117790.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported