ISA 27

• Description :

  ISA 27 is a small-molecule MDM2-p53 protein-protein interaction inhibitor. ISA 27 inhibits MDM2-mediated p53 ubiquitination and degradation. ISA 27 is promising for research of p53-mutant solid tumors (e.g., thyroid, breast cancer) [1].

• UNSPSC :

  12352005

• Target :

  MDM-2/p53

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C1[C@]2(C3=CC=CC=C3N1)N4[C@@](C(N(C4=O)CC5=CC=C(C=C5)Cl)=O)([H])CS2

• Molecular Formula :

  C19H14ClN3O3S

• Molecular Weight :

  399.85

• References & Citations :

  [1]Sorriento D, et al. New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53. Br J Cancer. 2015 Jan 6;112 (1) :77-85.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1254366-73-8]