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ISA 27

CAT: 0804-HY-124070Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-124070Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ISA 27 is a small-molecule MDM2-p53 protein-protein interaction inhibitor. ISA 27 inhibits MDM2-mediated p53 ubiquitination and degradation. ISA 27 is promising for research of p53-mutant solid tumors (e.g., thyroid, breast cancer) [1].
CAS Number
[1254366-73-8]
UNSPSC
12352005
Target
MDM-2/p53
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1[C@]2(C3=CC=CC=C3N1)N4[C@@](C(N(C4=O)CC5=CC=C(C=C5)Cl)=O)([H])CS2
Molecular Formula
C19H14ClN3O3S
Molecular Weight
399.85
References & Citations
[1]Sorriento D, et al. New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53. Br J Cancer. 2015 Jan 6;112 (1) :77-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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