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IRAK4-IN-27

CAT: 0804-HY-155574Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155574Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IRAK4-IN-27 (Compound 22) is a potent, selective inhibitor of IRAK4, with IC50 of 8.7 nM. IRAK4-IN-27 inhibits cell growth, and promotes apoptosis in MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line. IRAK4-IN-27 can be used for DLBCL study[1].
CAS Number
2626988-86-9
UNSPSC
12352005
Target
Apoptosis; IRAK
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/irak4-in-27.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=COC(C2=CC(N)=NC=C2)=N1)NC3=C(C4=CN(C)N=C4)C=C(OC(C)(C)C5)C5=C3
Molecular Formula
C23H22N6O3
Molecular Weight
430.46
References & Citations
[1]Chen Y, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma. Eur J Med Chem. 2023;256:115453.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4

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