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ISA-2011B

CAT: 0804-HY-16937-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16937-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ISA-2011B is a PIP5K1α inhibitor with promising anticancer effects .
CAS Number
[1395347-24-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI4P5K
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ISA-2011B.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@H](C2=CNC3=C2C=C(Cl)C=C3)C4=C(C=C5C(OCO5)=C4)C[C@]16[H])CN(C)C6=O
Molecular Formula
C22H18ClN3O4
Molecular Weight
423.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Semenas J, et al. The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer. Proc Natl Acad Sci U S A. 2014 Sep 2;111 (35) :E3689-98.|[2]Sarwar M, et al. Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes MDV3100 resistance in prostate cancer cells. Oncotarget. 2016 Sep 27;7 (39) :63065-63081.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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