SC-68448

CAT: 0804-HY-123864Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-123864Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SC-68448 (S 448) is a selective αvβ3 antagonist (IC50 = 1 nM) . SC-68448 inhibits αvβ3-mediated endothelial cell proliferation. SC-68448 reduces the total level of αvβ6 in NHBE cells. SC-68448 inhibits angiogenesis in a rat corneal neoplasia model. SC-68448 inhibits tumor growth and completely prevents the development of hypercalcemia in a rat Ledich cell tumor model. SC-68448 can be used in research on cardiovascular and cerebrovascular diseases such as hypercalcemia and cancers such as testicular interstitial cell tumors[1][2].
CAS Number
[188804-07-1]
Product Name Alternative
S 448
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(O)CC(NC(CNC(C1=CC=CC(NC(N)=N)=C1)=O)=O)C2=CC(Cl)=CC(Cl)=C2
Molecular Formula
C19H19Cl2N5O4
Molecular Weight
452.29
References & Citations
[1]Carron CP, et al. A peptidomimetic antagonist of the integrin alpha (v) beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Cancer Res. 1998 May 1;58 (9) :1930-5.|[2]Roper JA, et al. Downregulation of the αvβ6 Integrin via RGD Engagement Is Affinity and Time Dependent. J Pharmacol Exp Ther. 2021 Feb;376 (2) :273-280.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-107410-01SC-26196
HY-129982-01SC-435
HY-W010983-01SC-236
HY-136657-01SC-43
HY-100931-01SC-10
HY-103226-01SC-57461A
HY-102065-01SC-19220
HY-123354SC 44914
HY-19500-01SC-75416
HY-14237SC-77964

Alternative Products

CatalogName
M12956-01SC-68448
sc-51694SC (SC-05)
MD023023-12SC-PEG12-SC
HO023023-500-01SC-PEG-SC, 500
HO023023-4K-01SC-PEG-SC, 4K
HO023023-1K-01SC-PEG-SC, 1K
HO023023-10K-01SC-PEG-SC, 10K
HO023023-8K-01SC-PEG-SC, 8K
HO023023-6K-01SC-PEG-SC, 6K
HO023023-800-01SC-PEG-SC, 800

Popular Products