MK-7288

• Description :

  MK-7288 is a histamine H3 receptor inverse agonist. MK-7288 can prolong sleep latency in the Maintain Wake Test (MWT) . MK-7288 can be used in research on obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) [1][2].

• CAS Number :

  [936626-07-2]

• UNSPSC :

  12352005

• Target :

  Histamine Receptor

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  O=C([C@@H]1CC[C@]2(C3=CC=C(OC)N=C3C(O2)=O)CC1)N(C)CCN4CCCCC4

• Molecular Formula :

  C22H31N3O4

• Molecular Weight :

  401.50

• References & Citations :

  [1]Sun H, et al. Early-stage comparative effectiveness: randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients. J Clin Pharmacol. 2013 Dec;53 (12) :1294-302.|[2]Neshat SS, et al. Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review. Sleep Med Rev. 2024 Aug;76:101934.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1