MK-8325

• Description :

  MK-8325 (Compound 1) is an orally active HCV NS5A inhibitor. MK-8325 exhibits minimal inhibitory activity against hERG at a concentration of 30 mM. MK-8325 may be used in hepatitis C research[1].

• UNSPSC :

  12352005

• Target :

  HCV

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O=C(OC)N[C@@H](C(C)C)C(N1C[Si](C)(C)C[C@H]1C2=NC3=CC=C4C=C(C5=CC=C(C6=CN=C([C@H]7N(C([C@H](C(C)C)NC(OC)=O)=O)CC(F)(F)C7)N6)C=C5)C=CC4=C3N2)=O

• Molecular Formula :

  C43H52F2N8O6Si

• Molecular Weight :

  843.01

• References & Citations :

  [1]Nair AG, et al. MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV. Bioorg Med Chem Lett. 2018 Jun 1;28 (10) :1954-1957.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1334312-52-5]