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Gol-NTR

CAT: 0804-HY-151537-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-151537-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gol-NTR is a Golgi-targetable probe with high selectivity and sensitivity. Gol-NTR is Nitroreductase (NTR) -activated and has visualization acute lung injury (ALI) and repair function. Gol-NTR has a low detection limit of 54.8 ng/mL. Gol-NTR can be used for the research for monitoring and assessing research response of sepsis-induced ALI[1].
CAS Number
2968461-58-5
UNSPSC
12171500
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gol-ntr.html
Purity
99.44
Solubility
10 mM in DMSO
Smiles
FC(F)(C1=NC(C=C(NC(OCC2=CC=C([N+]([O-])=O)C=C2)=O)C=C3)=C3C(C4=CC=CC=C4)=C1)F
Molecular Formula
C24H16F3N3O4
Molecular Weight
467.40
References & Citations
[1]Tang Z, et al. Precise Monitoring and Assessing Treatment Response of Sepsis-Induced Acute Lung Hypoxia with a Nitroreductase-Activated Golgi-Targetable Fluorescent Probe. Anal Chem. 2022 Oct 25;94 (42) :14778-14784.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Chemical Information

Gol-NTR
CAS Number2968461-58-5
PubChem CID170901660
IUPAC Name(4-nitrophenyl)methyl N-[4-phenyl-2-(trifluoromethyl)quinolin-7-yl]carbamate
Molecular FormulaC24H16F3N3O4
Molecular Weight467.4
XLogP5.6
Topological Polar Surface Area97
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity703
SMILES
C1=CC=C(C=C1)C2=CC(=NC3=C2C=CC(=C3)NC(=O)OCC4=CC=C(C=C4)[N+](=O)[O-])C(F)(F)F
InChI
InChI=1S/C24H16F3N3O4/c25-24(26,27)22-13-20(16-4-2-1-3-5-16)19-11-8-17(12-21(19)29-22)28-23(31)34-14-15-6-9-18(10-7-15)30(32)33/h1-13H,14H2,(H,28,31)
InChIKey
WUKLKUQVRIVZCZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gol-NTR
CAS: 2968461-58-5
CID: 170901660
Formula: C24H16F3N3O4
MW: 467.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight467.4
XLogP35.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass467.10929049
Monoisotopic Mass467.10929049
Topological Polar Surface Area97 Ų
Heavy Atom Count34
Formal Charge0
Complexity703
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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