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PF-739

CAT: 0804-HY-117755-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117755-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2].
CAS Number
1852452-14-2
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-739.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@]([H])([C@@]2(OC1)[H])OC[C@H]2OC3=NC4=CC(C5=CC=C(C=C5)C6(CC6)CO)=C(C=C4N3)Cl
Molecular Formula
C23H23ClN2O5
Molecular Weight
442.89
References & Citations
[1]Aledavood E, et al. Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739[J]. Frontiers in Molecular Biosciences, 2021, 8: 760026.|[2] Cokorinos EC, et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab. 2017 May 2;25 (5) :1147-1159.e10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK α1β1γ1; AMPK α1β2γ1; AMPK α2β1γ1; AMPK α2β2γ1

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