PF-739

• Description :

  PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2].

• CAS Number :

  [1852452-14-2]

• UNSPSC :

  12352005

• Target :

  AMPK

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; PI3K/Akt/mTOR

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-739.html

• Purity :

  99.79

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O[C@H]1[C@]([H])([C@@]2(OC1)[H])OC[C@H]2OC3=NC4=CC(C5=CC=C(C=C5)C6(CC6)CO)=C(C=C4N3)Cl

• Molecular Formula :

  C23H23ClN2O5

• Molecular Weight :

  442.89

• References & Citations :

  [1]Aledavood E, et al. Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739[J]. Frontiers in Molecular Biosciences, 2021, 8: 760026.|[2] Cokorinos EC, et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab. 2017 May 2;25 (5) :1147-1159.e10.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AMPK α1β1γ1; AMPK α1β2γ1; AMPK α2β1γ1; AMPK α2β2γ1