PF-739

• Description:

  PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2].

• UNSPSC:

  12352005

• Target:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pf-739.html

• Purity:

  99.79

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1[C@] ([H]) ([C@@]2 (OC1) [H]) OC[C@H]2OC3=NC4=CC (C5=CC=C (C=C5) C6 (CC6) CO) =C (C=C4N3) Cl

• Molecular Formula:

  C23H23ClN2O5

• Molecular Weight:

  442.89

• References & Citations:

  [1]Aledavood E, et al. Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739[J]. Frontiers in Molecular Biosciences, 2021, 8: 760026.|[2] Cokorinos EC, et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab. 2017 May 2;25 (5) :1147-1159.e10.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AMPK α1β1γ1; AMPK α1β2γ1; AMPK α2β1γ1; AMPK α2β2γ1

• CAS Number:

  1852452-14-2