PF-04827736

• Description:

  PF-04827736 (compound (S) -3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11) . PF-04827736 can be used for the study of cardiovascular disease[1].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE)

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O(C)C=1C2=C(C(N[C@H](CC3=NNC(C)=C3)C)=NC=N2)C=CC1OC

• Molecular Formula:

  C17H21N5O2

• Molecular Weight:

  327.39

• References & Citations:

  [1]John M Humphrey, et al. Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1. J Med Chem. 2018 May 24;61 (10) :4635-4640.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDE1

• CAS Number:

  [2230054-75-6]