Org 6906

• Description :

  Org 6906 is a monoamine reuptake inhibitor that promotes monoaminergic neurotransmission by inhibiting the reuptake of noradrenaline, dopamine, and serotonin. Org 6906 is also an α2 Adrenergic Receptor antagonist, with a pKi value of 6.3 (using the selective α2 adrenergic receptor ligand [3H]rauwolscine as a ligand) . Org 6906 exhibits antidepressant activity and can be used in research related to neurological disorders[1].

• CAS Number :

  [67384-25-2]

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/org-6906.html

• Smiles :

  N[C@H]1[C@@]2([H])C[C@](C=C1)([H])C3=CC=CC=C3C2.Cl

• Molecular Formula :

  C13H16ClN

• Molecular Weight :

  221.73

• References & Citations :

  [1]de Boer T, et al. The pharmacological profile of Org 6906, a potential non-sedative antidepressant that combines monoamine uptake inhibition with alpha 2-adrenolytic activity. Neuropharmacology. 1988 Mar;27 (3) :251-60.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  α adrenergic receptor