SAS-0132

• Description:

  SAS-0132 is a selective Sigma 2 receptor (Sig2R) antagonist (Ki: 90 nM) that can cross the blood-brain barrier. SAS-0132 is capable of regulating intracellular Ca2+ levels and modulating PGRMC1-related pathways. SAS-0132 exhibits neuroprotective activity and can improve cognitive impairment in Alzheimer's disease mice. SAS-0132 can be used in the research of neurocognitive disorders such as Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Calcium Channel; Sigma Receptor

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  O=C (N1CC[C@]2 ([H]) C3=CC=C (N4CCN (C) CC4) C=C3[C@@]1 ([H]) C2) OCC5=CC=CC=C5

• Molecular Formula:

  C24H29N3O2

• Molecular Weight:

  391.51

• References & Citations:

  [1]Yi B, et al. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017 Feb;140 (4) :561-575.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2095551-89-4