SAS-0132

CAT: 0804-HY-119386Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-119386Size:1 Each
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Description
SAS-0132 is a selective Sigma 2 receptor (Sig2R) antagonist (Ki: 90 nM) that can cross the blood-brain barrier. SAS-0132 is capable of regulating intracellular Ca2+ levels and modulating PGRMC1-related pathways. SAS-0132 exhibits neuroprotective activity and can improve cognitive impairment in Alzheimer's disease mice. SAS-0132 can be used in the research of neurocognitive disorders such as Alzheimer's disease[1].
CAS Number
[2095551-89-4]
UNSPSC
12352005
Target
Calcium Channel; Sigma Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(N1CC[C@]2([H])C3=CC=C(N4CCN(C)CC4)C=C3[C@@]1([H])C2)OCC5=CC=CC=C5
Molecular Formula
C24H29N3O2
Molecular Weight
391.51
References & Citations
[1]Yi B, et al. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017 Feb;140 (4) :561-575.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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