JTE-013

• Description :

  JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  Apoptosis; LPL Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; GPCR/G Protein

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/jte-013.html

• Purity :

  99.92

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C1=C2C(N(C)N=C2C)=NC(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)=C1)C

• Molecular Formula :

  C17H19Cl2N7O

• Molecular Weight :

  408.29

• Precautions :

  H301

• References & Citations :

  [1]Li MH, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep;354 (3) :261-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [383150-41-2]