CP-664511

• Description:

  CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects (IC50=0.52 nM) . CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases[1].

• UNSPSC:

  12352005

• Target:

  Integrin

• Related Pathways:

  Cytoskeleton

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C (O) CCC1=CC ([C@@H] (NC (CC2=CC=C (NC (NC3=CC=CC=C3C) =O) C (OC) =C2) =O) CC (C) C) =NO1

• Molecular Formula:

  C28H34N4O6

• Molecular Weight:

  522.59

• References & Citations:

  [1]Kudlacz E, et al. Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists. J Pharmacol Exp Ther. 2002 May;301 (2) :747-52.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  α4β1

• CAS Number:

  379692-00-9