Bunitrolol (hydrochloride)

• Description:

  Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312+H332-H315-H319-H335

• Target:

  Adrenergic Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Cardiovascular Disease

• Smiles:

  N#CC1=CC=CC=C1OCC(CNC(C)(C)C)O.Cl

• Molecular Formula:

  C14H21ClN2O2

• Molecular Weight:

  284.78

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Tsuchihashi H, et al. Effects of bunitrolol on adrenergic and serotonergic receptors. Jpn J Pharmacol. 1987 Nov;45 (3) :349-56.|[2]Hasegawa Y, et al. Chronic effects of bunitrolol and pindolol on blood pressure, heart rate, vascular lesions, and plasma renin activity in hypertensive rats. Jpn J Pharmacol. 1982 Aug;32 (4) :742-5. |[3]Van Petten G R, et al. Chronic preparation of the pregnant ewe and fetus for pharmacological research: the placental transfer and fetal effects of bunitrolol. Journal of Pharmacological Methods, 1978, 1 (1) : 45-60.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  β adrenergic receptor

• CAS Number:

  [29876-08-2]