Bunitrolol

• Description :

  Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research[1][2][3].

• Product Name Alternative :

  KO 1366

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H315, H319, H332, H335

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/bunitrolol.html

• Purity :

  95.0

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC1=CC=CC=C1OCC(CNC(C)(C)C)O

• Molecular Formula :

  C14H20N2O2

• Molecular Weight :

  248.32

• Precautions :

  H302, H312, H315, H319, H332, H335

• References & Citations :

  [1]Tsuchihashi H, et al. Effects of bunitrolol on adrenergic and serotonergic receptors. Jpn J Pharmacol. 1987 Nov;45 (3) :349-56. |[2]Hasegawa Y, et al. Chronic effects of bunitrolol and pindolol on blood pressure, heart rate, vascular lesions, and plasma renin activity in hypertensive rats. Jpn J Pharmacol. 1982 Aug;32 (4) :742-5.|[3]Van Petten G R, et al. Chronic preparation of the pregnant ewe and fetus for pharmacological research: the placental transfer and fetal effects of bunitrolol. Journal of Pharmacological Methods, 1978, 1 (1) : 45-60.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  β adrenergic receptor

• CAS Number :

  [34915-68-9]