CP-283097

CAT: 0804-HY-116142Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-116142Size:1 Each
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Description
CP-283097 is an orally active and conformationally restricted and NR2B subtype-selective NMDA antagonist. CP-283097 efficiently competitively inhibits the binding of [³H]CP-101,606 to the rat meninges, with an IC50 value of 18 nM. CP-283097 exhibits nearly complete inhibition of the current mediated by the NR2B receptor (IC50 = 206 nM), while the inhibitory effect on the NR2A or NR2C receptors is very weak. CP-283097 demonstrates excellent central nervous system permeability and in vivo efficacy in animal models. CP-283097 can be used for neurological diseases related to excessive activation of NMDA receptors[1].
CAS Number
[138047-56-0]
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O[C@@H]1[C@H](N2CCC(O)(CC2)CC3=CC=CC=C3)COC4=CC(O)=CC=C41
Molecular Formula
C21H25NO4
Molecular Weight
355.43
References & Citations
[1]Butler TW, et al. (3R,4S) -3-[4- (4-fluorophenyl) -4-hydroxypiperidin-1-yl]chroman-4,7-diol: a conformationally restricted analogue of the NR2B subtype-selective NMDA antagonist (1S,2S) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidino) - 1-propanol. J Med Chem. 1998 Mar 26;41 (7) :1172-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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