CP-288886

• Description:

  CP-288886 is a cysLT1 receptor antagonist with a Ki value of 0.004 μM. CP-288886 exhibits comparable activity to Zafirlukast (HY-17492) and Pranlukast (HY-B0290) . CP-288886 inhibits calcium mobilization with an IC50 of 0.0005 μM in human U937 cells. CP-288886 has high oral bioavailability. CP-288886 possesses anti-asthmatic activity in a guinea pig asthma model and can be used for the research of diseases such as asthma[1].

• UNSPSC:

  12352005

• Target:

  Calcium Channel; Leukotriene Receptor

• Related Pathways:

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O[C@H]1C2=CC (OCC3=NC4=CC (Cl) =CC=C4C=C3) =CC=C2OC (C) (C) [C@H]1CC5=C (C=CC (NS (C (F) (F) F) (=O) =O) =C5) OC

• Molecular Formula:

  C30H28ClF3N2O6S

• Molecular Weight:

  637.07

• References & Citations:

  [1]Chambers RJ, et al. Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists. Bioorg Med Chem Lett. 1998 Dec 15;8 (24) :3577-82.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  LTD4/CysLT1

• CAS Number:

  221332-74-7