CGP-74514

• Description:

  CGP-74514 (Compound 13) is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC50=25 nM) . CGP-74514 inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G2/M phase and induces tumor cell apoptosis. CGP-74514 is promising for research of bladder cancer[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis; CDK

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Purity:

  98.02

• Smiles:

  CCN1C=NC2=C(NC3=CC=CC(Cl)=C3)N=C(N[C@H]4[C@@H](N)CCCC4)N=C12

• Molecular Formula:

  C19H24ClN7

• Molecular Weight:

  385.89

• References & Citations:

  [1]Furet P, et al. Structure-based design of potent CDK1 inhibitors derived from olomoucine. J Comput Aided Mol Des. 2000 Jul;14 (5) :403-9.|[2]Imbach P, et al. 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9 (1) :91-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK1

• CAS Number:

  [190653-73-7]