SKI-73

• Description :

  SKI-73 is a chemical probe for CARM1 with prodrug properties. SKI-73 can rapidly penetrate cell membranes and be processed into active inhibitors. SKI-73 inhibits the invasion of breast cancer cells and can be used in the study of cancer[1].

• CAS Number :

  [2206744-61-6]

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase

• Related Pathways :

  Epigenetics

• Field of Research :

  Cancer

• Smiles :

  O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1C[C@@H](CNCC4=CC=CC=C4)CC[C@@H](C(NCCC5=CC=C(OC)C=C5)=O)NC(CC(C)(C)C6=C(C)C(C(C)=C(C)C6=O)=O)=O

• Molecular Formula :

  C46H58N8O8

• Molecular Weight :

  851.00

• References & Citations :

  [1]Cai XC, et al. A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife. 2019 Oct 28;8:e47110.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported