SKI-I

• Description :

  SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM) . SKI-I induces apoptosis in tumor cell lines[1][2].

• Product Name Alternative :

  Rebemadlin

• UNSPSC :

  12352005

• Target :

  Apoptosis; SphK

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ski-i.html

• Purity :

  99.73

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=NNC(C2=CC=C3C=CC=CC3=C2)=C1)N/N=C/C4=C5C=CC=CC5=CC=C4O

• Molecular Formula :

  C25H18N4O2

• Molecular Weight :

  406.44

• References & Citations :

  [1]French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63 (18) :5962-9.|[2]Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep;45 (9) :4149-56.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [306301-68-8]