SKI V

CAT: 0804-HY-12895-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12895-01Size:5 mg
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Description
SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) . SKI V induces apoptosis and has antitumor activity[1][2].
CAS Number
[24418-86-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; PI3K; SphK
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ski-v.html
Purity
98.95
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1/C(OC2=CC=CC=C12)=C/C3=CC=C(O)C(O)=C3
Molecular Formula
C15H10O4
Molecular Weight
254.24
Precautions
H302, H315, H319
References & Citations
[1]French KJ, et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63 (18) :5962-9.|[2]French KJ, et al. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318 (2) :596-603.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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