SC-53228

CAT: 0804-HY-112740Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-112740Size:1 Each
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Description
SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis[1][2].
CAS Number
[153633-01-3]
UNSPSC
12352005
Target
Leukotriene Receptor
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CCCC1=C2C(CC[C@H](O2)CCC(O)=O)=CC=C1OCCCOC3=C(C(OC)=C(C=C3)C(NC)=O)CC4CC4
Molecular Formula
C31H41NO7
Molecular Weight
539.66
References & Citations
[1]Fretland DJ, et al. Dermal inflammation in primates, mice, and guinea pigs: attenuation by second-generation leukotriene B4 receptor antagonist, SC-53228. Inflammation. 1995 Jun;19 (3) :333-46. |[2]Fretland D, et al. Oral efficacy of a leukotriene B4 receptor antagonist in colitic cotton-top tamarins. Gut. 1995 Nov;37 (5) :702-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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