MGS 0210

• Description :

  MGS 0210 (BCI 838) is an orally active metabolite of glutamate receptor 2/3 (mGluR2/3) agonists. MGS 0210 improves amnesia and reduces anxiety in APP mice. MGS 0210 improves PTSD-related behaviors in a mouse model of post-traumatic stress disorder (PTSD) . MGS 0210 can be used in research on neurological disorders such as Alzheimer's disease and major depressive disorder[1][2].

• Product Name Alternative :

  BCI 838

• UNSPSC :

  12352005

• Target :

  MGluR

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  CCCCCCCOC([C@@]1([C@]2([H])[C@@]1([H])C[C@@H](OCC3=CC(Cl)=C(Cl)C=C3)[C@@]2(N)C(O)=O)F)=O

• Molecular Formula :

  C22H28Cl2FNO5

• Molecular Weight :

  476.37

• References & Citations :

  [1]Kim SH, et al.. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Mol Psychiatry. 2014 Nov;19 (11) :1235-42.|[2]Tschiffely AE, et al. Blast-induced "PTSD": Evidence from an animal model. Neuropharmacology. 2019 Feb;145 (Pt B) :220-229.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [820244-38-0]