CTCE-0214

• Description :

  CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research[1][2][3].

• UNSPSC :

  12352209

• Target :

  CXCR

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ctce-0214.html

• Purity :

  99.96

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]2N(CCC2)C([C@@H](N)CCCCN)=O)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CO)=O)CC3=CC=C(C=C3)O)=O)CCCNC(N)=N)=O)C)=O)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)CC(C)C)=O)CCCCN7)=O)CC8=CNC9=C8C=CC=C9)=O)[C@H](CC)C)=O)CCC(N)=O)=O)CCC7=O)=O)CC%10=CC=C(C=C%10)O)=O)CC(C)C)=O)CCC(O)=O)=O)CCCCN)=O)C)=O)CC(C)C)=O)C(N)=O)N

• Molecular Formula :

  C170H254N44O40

• Molecular Weight :

  3554.11

• References & Citations :

  [1]Fan H, et al. Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation. 2012 Feb;35 (1) :130-7.|[2]Faber A, et al. The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J Biomed Biotechnol. 2007;2007 (3) :26065.|[3]Li K, et al. Small peptide analogue of SDF-1alpha supports survival of cord blood CD34+ cells in synergy with other cytokines and enhances their ex vivo expansion and engraftment into nonobese diabetic/severe combined immunodeficient mice. Stem Cells. 2006 Jan;24 (1) :55-64.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  Phase 1

• Isoform :

  CXCR4

• CAS Number :

  [577782-52-6]