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(S) -V-0219

CAT: 0804-HY-143312CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143312CSize:1 Each
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Description
(S) -V-0219 is an enantiomer of V-0219. V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (S) -V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R. (S) -V-0219 is orally active and ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice[1].
CAS Number
3031984-78-5
UNSPSC
12352005
Target
GLP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s-v-0219.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC=C(C2=NOC(CN3C[C@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F
Molecular Formula
C20H25F3N4O2
Molecular Weight
410.43
References & Citations
[1]Decara JM, et, al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65 (7) :5449-5461.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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