PF-03671148

• Description:

  PF-03671148 is an ALK5 inhibitor. PF-03671148 can reduce TGFβ induced fibrotic gene expression in fibroblasts. PF-03671148 has potential utility for the prevention of dermal scarring[1].

• UNSPSC:

  12352005

• Target:

  Anaplastic lymphoma kinase (ALK)

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Others

• Smiles:

  O=C1C2=C (N=CN1C) C=CC (C3=CC=NN3C4=CC=CC (C) =N4) =C2

• Molecular Formula:

  C18H15N5O

• Molecular Weight:

  317.34

• References & Citations:

  [1]Boys ML, et al. Discovery of a series of 2- (1H-pyrazol-1-yl) pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring. Bioorg Med Chem Lett. 2012 May 15;22 (10) :3392-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1378524-25-4