KB R6933

• Description:

  KB R6933 (KB 6806 maleate) is a potent, selective and orally active 5-HT3 receptor antagonist. KB R6933 can inhibit the diarrhea induced by 5-HT (HY-B1473A), but not that by Castor Oil (HY-107799) or prostaglandin E2 (PGE2) (HY-101952) . KB R6933 can inhibit 5-HT-induced bradycardia[1][2].

• Product Name Alternative:

  KB 6806 (maleate)

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  OC(/C=C\C(O)=O)=O.CC(N1C(N2CCN(CC2)C)=NC3=CC(Cl)=C(N)C=C31)C.OC(/C=C\C(O)=O)=O

• Molecular Formula:

  C23H30ClN5O8

• Molecular Weight:

  539.97

• References & Citations:

  [1]Ozaki A, et al. Effect of the 5-hydroxytryptamine3 (5-HT3) -receptor antagonist KB-R6933 on experimental diarrhea models. Jpn J Pharmacol. 1999 May;80 (1) :93-6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT3 Receptor

• CAS Number:

  [148565-09-7]