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KB 5666

CAT: 0804-HY-117578Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117578Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KB 5666 is a benzoxazine derivative with lipid peroxidation inhibitory activity. KB 5666 showed protective effects against post-ischemic neuronal death. KB 5666 effectively protected CA1 neurons when injected 5 minutes before or immediately after ischemia. KB 5666 also showed a dose-dependent protective effect when injected within 1 hour after ischemia. KB 5666 effectively prevented the significant decrease in microtubule-associated protein 2 immunoreactivity within the dendritic field of CA1 pyramidal cells. KB 5666 prevented the decrease in [3H]PDBu binding activity in different layers of the CA1 region after ischemia. The application of KB 5666 showed the ability to improve the cellular and functional consequences of ischemia[1].
CAS Number
131916-69-3
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kb-5666.html
Smiles
C=CCN1CCN(CC1)C2=NC(OCCCCC)=C3C=CC=CC3=N2.O=C(/C=C/C(O)=O)O
Molecular Formula
C24H32N4O5
Molecular Weight
456.53
References & Citations
[1]Prevention of hippocampus neuronal damage in ischemic gerbils by a novel lipid peroxidation inhibitor (quinazoline derivative)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19200143-01KB 5666

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