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Thonzonium (bromide) (Standard)

CAT: 0804-HY-B1246RSize: 1 EachDry Ice: NoHazardous: No
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Description
Thonzonium (bromide) (Standard) is the analytical standard of Thonzonium (bromide). This product is intended for research and analytical applications. Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol. Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM)[2][3].
CAS Number
553-08-2
UNSPSC
12352005
Target
Bacterial; Proton Pump; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thonzonium-bromide-standard.html
Smiles
CCCCCCCCCCCCCCCC[N+](C)(CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2)C.[Br-]
Molecular Formula
C32H55BrN4O
Molecular Weight
591.71
References & Citations
[1]Zhu X, et al. Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Biochem Pharmacol. 2016;104:118-130.|[2]Chan CY, et al. Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p) . J Biol Chem. 2012;287 (13) :10236-10250.|[3]Sims KR, et al. Enhanced design and formulation of nanoparticles for anti-biofilm drug delivery. Nanoscale. 2018;11 (1) :219-236.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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