AZD-1236

• Description :

  AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12.

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  MMP

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Smiles :

  C[C@@]1(NC(NC1=O)=O)CS(=O)(N2CCC(CC2)OC3=CC=C(C=N3)Cl)=O

• Molecular Formula :

  C15H19ClN4O5S

• Molecular Weight :

  402.85

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Magnussen H, Watz H, Kirsten A, Wang M, Wray H, Samuelsson V, Mo J, Kay R. Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: a randomised controlled 6-week trial. Pulm Pharmacol Ther. 2011 Oct;24 (5) :563-70.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  MMP-12; MMP-9

• CAS Number :

  [459814-89-2]