AZD-1236

• Description:

  AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12.

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  MMP

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Smiles:

  C[C@@]1(NC(NC1=O)=O)CS(=O)(N2CCC(CC2)OC3=CC=C(C=N3)Cl)=O

• Molecular Formula:

  C15H19ClN4O5S

• Molecular Weight:

  402.85

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Magnussen H, Watz H, Kirsten A, Wang M, Wray H, Samuelsson V, Mo J, Kay R. Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: a randomised controlled 6-week trial. Pulm Pharmacol Ther. 2011 Oct;24 (5) :563-70.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  MMP-12; MMP-9

• CAS Number:

  [459814-89-2]