AZD-1236

CAT: 0931-T69230-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T69230-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
459814-89-2
Target
MMP|||Others
Related Pathways
Others|||Proteases/Proteasome
Bioactivity
AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished macrophage infiltration into BAL fluid induced by tobacco smoke inhalation in the mouse.
Smiles
S(C[C@@]1(C)NC(=O)NC1=O)(=O)(=O)N2CCC(OC3=CC=C(Cl)C=N3)CC2
Molecular Formula
C15H19ClN4O5S
Molecular Weight
402.85
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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