AZD-1236

• Target:

  MMP|||Others

• Related Pathways:

  Others|||Proteases/Proteasome

• Bioactivity:

  AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished macrophage infiltration into BAL fluid induced by tobacco smoke inhalation in the mouse.

• Smiles:

  S (C[C@@]1 (C) NC (=O) NC1=O) (=O) (=O) N2CCC (OC3=CC=C (Cl) C=N3) CC2

• Molecular Formula:

  C15H19ClN4O5S

• Molecular Weight:

  402.85

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  459814-89-2