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Lu AF21934 (Standard)

CAT: 0804-HY-100366RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100366RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lu AF21934 (Standard) is the analytical standard of Lu AF21934. This product is intended for research and analytical applications. Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an EC50 of 500 nM for mGlu4 receptor[1].
CAS Number
1445605-23-1
Target
MGluR; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C([C@@H]1[C@H](C(N)=O)CCCC1)NC2=CC=C(Cl)C(Cl)=C2
Molecular Formula
C14H16Cl2N2O2
Molecular Weight
315.20
References & Citations
[1]Anna Sławińska, et al. Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu? receptor. Neuropharmacology. 2013 Mar;66:225-35.|[2]Ossowska K, et al. Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. Neuropharmacology. 2014 Aug;83:28-35.|[3]Anna Sławińska, et al. The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4 receptors in rodents. Br J Pharmacol. 2013 Aug;169 (8) :1824-39.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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