MK-4101

CAT: 0804-HY-100036-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100036-01Size:2 mg
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Description
MK-4101 is a Smoothened (SMO) antagonist (IC50 of 1.1 μM for 293 cells) and also a potent inhibitor of the hedgehog pathway (IC50 of 1.5 μM for mouse cells; IC50 of 1 μM for KYSE180 oesophageal cancer cells) . MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis[1].
CAS Number
[935273-79-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Hedgehog; Smo
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MK-4101.html
Purity
99.16
Solubility
DMSO : ≥ 50 mg/mL
Smiles
FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F
Molecular Formula
C24H24F5N5O
Molecular Weight
493.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Filocamo G et al. MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. Mol Cancer Ther. 2016 Jun;15 (6) :1177-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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