MK-4101

• Description:

  MK-4101 is a Smoothened (SMO) antagonist (IC50 of 1.1 μM for 293 cells) and also a potent inhibitor of the hedgehog pathway (IC50 of 1.5 μM for mouse cells; IC50 of 1 μM for KYSE180 oesophageal cancer cells) . MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Hedgehog; Smo

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MK-4101.html

• Purity:

  99.16

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F

• Molecular Formula:

  C24H24F5N5O

• Molecular Weight:

  493.47

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Filocamo G et al. MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. Mol Cancer Ther. 2016 Jun;15 (6) :1177-89.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [935273-79-3]