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MS 39

CAT: 0931-T41156Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T41156Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2675490-92-1
Target
Others|||EGFR|||PROTACs
Related Pathways
PROTAC|||Others|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis
Bioactivity
MS 39 is a highly effective, highly affinity and selective depressant of mutant epidermal growth factor receptor (EGFR) with high efficiency, high affinity and selectivity. MS 39, conjured by gefitinib to VHL ligand via a linker, effectively induced the degradation of mutant EGFR (DC50 values in HCC827 (exon 19 del) and H3255 (L858R mutation) lung cancer cell lines were 5 nM and 3.3 nM, respectively) . However, there was no significant effect in wild-type EGFR cell lines with concentrations up to 10 ?M. MS 39 inhibited the proliferation of H3255 lung cancer cells in vitro and was bioavailable in mice after administration.
Smiles
N(C=1C2=C(C=C(OC)C(OCCCN3CCN(C(CCCCCCCCCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)[C@@](C)(C)C)=O)=O)CC3)=C2)N=CN1)C7=CC(Cl)=C(F)C=C7
Molecular Formula
C55H71ClFN9O7S
Molecular Weight
1056.72
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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