Cyclo (CLLFVY)

CAT: 0931-TP2717-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-TP2717-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1446322-73-1

Target

VEGFR, HIF/HIF Prolyl-Hydroxylase

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis, Chromatin/Epigenetic, Metabolism

Bioactivity

Cyclo (CLLFVY) is an inhibitor of hypoxia-inducible factor-1 (HIF-1), exhibiting half-maximal inhibitory concentrations (IC50) of 19 μM in U2OS cells and 16 μM in MCF-7 cells. It binds to the PAS-B domain of HIF-1α, inhibiting the dimerization and transcriptional activity of HIF-1. Moreover, cyclo (CLLFVY) downregulates the expression of hypoxia response genes (such as VEGF and CAIX), demonstrating antitumor effects against HIF-1-related cancers.

Smiles

C([C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](C(C)C)NC1=O)C3=CC=CC=C3

Molecular Formula

C38H54N6O7S

Molecular Weight

738.94

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
CRB1001365-01	Cyclo (CLLFVY)
MBS5764041	TAT-cyclo-CLLFVY
MBS5817847	TAT-cyclo-CLLFVY TFA
A22796-10	TAT-cyclo-CLLFVY 10mg
A22796-5	TAT-cyclo-CLLFVY 5mg
CRB1001365-01	Cyclo (CLLFVY) - (Cancer Peptides)
HY-P1420A	TAT-cyclo-CLLFVY (TFA)
A22796-1	TAT-cyclo-CLLFVY 1mg
MBS406125-01	cyclo
M30392-01	Cyclo (RGDyK)

Cyclo (CLLFVY)

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