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WQQ-345

CAT: 0931-T89876-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89876-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Histone Methyltransferase, Dehydrogenase, Others
Related Pathways
Metabolism, Others, Chromatin/Epigenetic
Bioactivity
WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces α-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive activity in a 67R subcutaneous xenograft model.
Molecular Formula
C10H17NO2
Molecular Weight
183.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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