WQQ-345

• Target:

  Histone Methyltransferase|||Dehydrogenase|||Others

• Related Pathways:

  Metabolism|||Others|||Chromatin/Epigenetic

• Bioactivity:

  WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces ?-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive activity in a 67R subcutaneous xenograft model.

• Molecular Formula:

  C10H17NO2

• Molecular Weight:

  183.25

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C