WQQ-345

CAT: 0931-T89876-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T89876-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Histone Methyltransferase|||Dehydrogenase|||Others
Related Pathways
Metabolism|||Others|||Chromatin/Epigenetic
Bioactivity
WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces ?-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive activity in a 67R subcutaneous xenograft model.
Molecular Formula
C10H17NO2
Molecular Weight
183.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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