MI-3454

• Target:

  Histone Methyltransferase|||Epigenetic Reader Domain

• Related Pathways:

  Chromatin/Epigenetic

• Purity:

  0.9968

• Bioactivity:

  MI-3454 is an orally active, selective and potent inhibitor of Menin-MLL1 interaction that inhibits the proliferation and induces differentiation of acute leukemia cells with MLL1 translocation or NPM1 mutation.MI-3454 induces complete remission or regression of leukemia in a mouse model of leukemia with MLL1 rearrangement or NPM1 mutation through the down-regulation of key genes involved in leukemogenesis. complete remission or remission.

• Smiles:

  CNc1nc(NC2CCN(Cc3ccc4n(CC56CC(C5)(C6)NC=O)c(cc4c3C)C#N)CC2)c2cc(CC(F)(F)F)sc2n1

• Molecular Formula:

  C32H35F3N8OS

• Molecular Weight:

  636.73

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2134169-43-8