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PROTAC BRD4 Degrader-27

CAT: 0931-T89867-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89867-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2407163-44-2
Target
PROTACs, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.
Smiles
O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCC(=O)NC=4C=CC(OC5=CC=C(F)C=C5F)=C(C4)C6=CN(C(=O)C=7NC=CC67)C)C3C2=O)CC1
Molecular Formula
C37H30F2N6O7
Molecular Weight
708.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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