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SN-38-d3

CAT: 0931-T89645-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T89645-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
718612-49-8
Target
ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
SN-38-d3 is a deuterated form of SN-38. As the active metabolite of the topoisomerase I (TopoisomeraseI) inhibitor irinotecan, SN-38 (NK012) notably inhibits the synthesis of DNA and RNA, with IC50 values of 0.077 and 1.3 μM, respectively.
Smiles
C(C([2H])([2H])[2H])C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5
Molecular Formula
C22H20N2O5
Molecular Weight
395.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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