SN-38-d3

• Target:

  ADC Cytotoxin

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Bioactivity:

  SN-38-d3 is a deuterated form of SN-38. As the active metabolite of the topoisomerase I (TopoisomeraseI) inhibitor irinotecan, SN-38 (NK012) notably inhibits the synthesis of DNA and RNA, with IC50 values of 0.077 and 1.3 ?M, respectively.

• Smiles:

  C (C ([2H]) ([2H]) [2H]) C1=C2C (C=3N (C2) C (=O) C4=C (C3) [C@] (CC) (O) C (=O) OC4) =NC=5C1=CC (O) =CC5

• Molecular Formula:

  C22H20N2O5

• Molecular Weight:

  395.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  718612-49-8