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MAC glucuronide α-hydroxy lactone-linked SN-38

CAT: 0931-T18722-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T18722-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2246380-70-9
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a cytotoxic drug linker that maintains a stabilized lactone form, demonstrating efficacy against L540cy and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].
Smiles
O=C1N2C(C=3C(C2)=C(CC)C=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@]5(OCN(C(OCC6=CC(NC(CN(C(CCN7C(=O)C=CC7=O)=O)C)=O)=C(O[C@@H]8O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]8O)C=C6)=O)CCS(C)(=O)=O)CC
Molecular Formula
C50H54N6O20S
Molecular Weight
1091.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-128942MAC glucuronide α-hydroxy lactone-linked SN-38
MBS3842871-01MAC glucuronide alpha-hydroxy lactone-linked SN-38
A18407-10MAC glucuronide α -hydroxy lactone-linked SN-38 10mg
A18407-5MAC glucuronide α -hydroxy lactone-linked SN-38 5mg
A18407-1MAC glucuronide α -hydroxy lactone-linked SN-38 1mg
A18407-25MAC glucuronide α -hydroxy lactone-linked SN-38 25mg
WPD38069-01Mac glucuronide phenol-linked sn-38
A18403-5MAC glucuronide phenol-linked SN-38 5mg
A18403-1MAC glucuronide phenol-linked SN-38 1mg
A18403-10MAC glucuronide phenol-linked SN-38 10mg

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