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MAC glucuronide phenol-linked SN-38

CAT: 0931-T18538-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T18538-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2246380-69-6
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
MAC glucuronide phenol-linked SN-38, a pH-sensitive lactone and DNA topoisomerase I inhibitor drug linker, exhibits cytotoxicity in L540cy and Ramos cells, with IC50 values of 113 ng/mL and 67 ng/mL, respectively[1].
Smiles
CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCN(CCS(C)(=O)=O)C(=O)OCc3ccc(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)c(NC(=O)CN(C)C(=O)CCN4C(=O)C=CC4=O)c3)cc12
Molecular Formula
C50H54N6O20S
Molecular Weight
1091.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
WPD38069-01Mac glucuronide phenol-linked sn-38
A18403-5MAC glucuronide phenol-linked SN-38 5mg
A18403-1MAC glucuronide phenol-linked SN-38 1mg
A18403-10MAC glucuronide phenol-linked SN-38 10mg
HY-128942MAC glucuronide α-hydroxy lactone-linked SN-38
MBS5771582MAC glucuronide alpha-hydroxy lactone-linked SN-38
A18407-5MAC glucuronide α -hydroxy lactone-linked SN-38 5mg
A18407-1MAC glucuronide α -hydroxy lactone-linked SN-38 1mg
A18407-25MAC glucuronide α -hydroxy lactone-linked SN-38 25mg
A18407-10MAC glucuronide α -hydroxy lactone-linked SN-38 10mg

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