SN-38

• Target:

  ADC Cytotoxin|||Autophagy|||Drug Metabolite|||DNA/RNA Synthesis|||Topoisomerase

• Related Pathways:

  Autophagy|||Metabolism|||Antibody-drug Conjugate/ADC Related|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Purity:

  0.9997

• Bioactivity:

  SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 ?M) . SN-38 has antitumor activity and induces autophagy.

• Smiles:

  C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5

• Molecular Formula:

  C22H20N2O5

• Molecular Weight:

  392.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  86639-52-3