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SN-398

CAT: 0931-T88266-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T88266-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
124623-00-3
Target
Topoisomerase
Related Pathways
DNA Damage/DNA Repair
Bioactivity
SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 ?M) . SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells.
Smiles
O=C1N2C(C=3C(C2)=C(CC)C=4C(N3)=CC(F)=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O
Molecular Formula
C22H19FN2O5
Molecular Weight
410.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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