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Mal-va-mac-SN38

CAT: 0931-T89377-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89377-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2778229-31-3
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Mal-va-mac-SN38 is a conjugate molecule functioning as an ADC (Antibody-Drug Conjugate) drug-linker. This compound comprises the cytotoxic ADC agent SN-38 and a linker. Once inside the body, Mal-va-mac-SN38 rapidly forms a covalent bond with endogenous albumin, resulting in the formation of HSA-va-mac-SN38. It demonstrates remarkable stability in human plasma and exhibits both antitumor and antimetastatic properties.
Smiles
C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OCN(C(OCC6=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN7C(=O)C=CC7=O)=O)C(C)C)=O)C)=O)C=C6)=O)CCS(C)(=O)=O)=CC5
Molecular Formula
C52H61N7O14S
Molecular Weight
1040.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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