SA-VA

• Target:

  Ephrin Receptor|||VEGFR|||Apoptosis|||PROTACs

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||PROTAC|||Apoptosis

• Bioactivity:

  SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells. This compound undergoes in situ conversion to active PROTAC via a copper-catalyzed click reaction utilizing endogenous copper present in tumor tissues. Additionally, SA-VA induces apoptosis and arrests cell cycle progression in the S phase [1].

• Molecular Formula:

  C50H53ClF3N11O7S

• Molecular Weight:

  1044.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C