SA-VA

CAT: 0931-T79531-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T79531-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ephrin Receptor|||VEGFR|||Apoptosis|||PROTACs
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||PROTAC|||Apoptosis
Bioactivity
SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells. This compound undergoes in situ conversion to active PROTAC via a copper-catalyzed click reaction utilizing endogenous copper present in tumor tissues. Additionally, SA-VA induces apoptosis and arrests cell cycle progression in the S phase [1].
Molecular Formula
C50H53ClF3N11O7S
Molecular Weight
1044.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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