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SA-VA

CAT: 0931-T79531-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79531-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ephrin Receptor, VEGFR, Apoptosis, PROTACs
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, PROTAC, Apoptosis
Bioactivity
SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells. This compound undergoes in situ conversion to active PROTAC via a copper-catalyzed click reaction utilizing endogenous copper present in tumor tissues. Additionally, SA-VA induces apoptosis and arrests cell cycle progression in the S phase [1].
Molecular Formula
C50H53ClF3N11O7S
Molecular Weight
1044.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-155685SA-VA
HO358358-2KVA-PEG-VA, 2K
HO358358-10KVA-PEG-VA, 10K
HO358358-1KVA-PEG-VA, 1K
HO358358-5KVA-PEG-VA, 5K
HO358358-20KVA-PEG-VA, 20K
HO358358-3.4KVA-PEG-VA, 3.4K
F0011-31Factor Va
abx085045-01SA-PEG-SA
215589COX5A (COX-VA, COX, VA) discontinued

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