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Mal-va-mac-SN38

CAT: 0804-HY-159563-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-159563-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mal-va-mac-SN38 is a drug-linker conjugate for ADC. Mal-va-mac-SN38 contains a ADC cytotoxin SN-38 and a linker (HY-126364). Mal-va-mac-SN38 can rapidly and covalently bind with endogenous albumin in vivo, resulting in the formation of HSA-va-mac-SN38. Mal-va-mac-SN38 demonstrates exceptional stability in human plasma, and has anti-tumor and anti-metastasis effect[1].
CAS Number
2778229-31-3
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-va-mac-sn38.html
Purity
97.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(COC1=CC=C(N=C(C(N2C3)=CC([C@@](O)(CC)C(OC4)=O)=C4C2=O)C3=C5CC)C5=C1)CCS(=O)(C)=O)OCC6=CC=C(NC([C@@H](NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)C)=O)C=C6
Molecular Formula
C52H61N7O14S
Molecular Weight
1040.14
References & Citations
[1]Lu Y, et al. Design, synthesis, and biological evaluation of cathepsin B cleavage albumin-binding SN38 prodrug in breast cancer. Bioorg Chem. 2024 Jun;147:107370.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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